Dataset Information


Comparative gene expression profiling of group-housed, less aggressive vs. single-housed, more aggressive male flies

ABSTRACT: Social experience influences multiple behaviors of many animal species, including aggression. Social isolation often increases aggressiveness. To investigater the molecular basis of social influences on aggressiveness, we performed comparative gene expression profiling on heads from 6-day-old, single-housed, more aggressive and group-housed, less aggressive male flies. Keywords: social experience Overall design: 1 (single-housed) or 10 (group-housed) male flies were housed in plastic vials after eclosion for 6 days. Between 5-6pm on the 6th day, flies were frozen and their heads were harvested for Trizol RNA extraction and microarray experiment. Both single- and group-housing groups contained 3 biological replicates, which had a sampling pool of 20 heads.


INSTRUMENT(S): [Drosophila_2] Affymetrix Drosophila Genome 2.0 Array

SUBMITTER: Liming Wang  

PROVIDER: GSE6994 | GEO | 2008-02-08



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A common genetic target for environmental and heritable influences on aggressiveness in Drosophila.

Wang Liming L   Dankert Heiko H   Perona Pietro P   Anderson David J DJ  

Proceedings of the National Academy of Sciences of the United States of America 20080411 15

Environmental and genetic factors can modulate aggressiveness, but the biological mechanisms underlying their influence are largely unknown. Social experience with conspecifics suppresses aggressiveness in both vertebrate and invertebrate species, including Drosophila. We searched for genes whose expression levels correlate with the influence of social experience on aggressiveness in Drosophila by performing microarray analysis of head tissue from socially isolated (aggressive) vs. socially expe  ...[more]

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