Dataset Information


Transcriptional control of amino acid biosynthesis

ABSTRACT: We transcriptional profiled four transcription factor knockout strains in S288C background growing in YNB media + 2% glucose to understand the link between mRNA levels and our measured C13 fluxes of amino acid biosynthesis. We conducted this analysis as a follow up to our work on the Gcn4p transcription factor. Keywords: genetic modification Overall design: Multiple biological replicates were conducted for four transcription factor knockout strains

INSTRUMENT(S): MIT S.cerevisiae ORF 15K version 4.2

SUBMITTER: Joel Moxley  

PROVIDER: GSE7369 | GEO | 2008-03-18



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Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p.

Moxley Joel F JF   Jewett Michael C MC   Antoniewicz Maciek R MR   Villas-Boas Silas G SG   Alper Hal H   Wheeler Robert T RT   Tong Lily L   Hinnebusch Alan G AG   Ideker Trey T   Nielsen Jens J   Stephanopoulos Gregory G  

Proceedings of the National Academy of Sciences of the United States of America 20090403 16

Genome sequencing dramatically increased our ability to understand cellular response to perturbation. Integrating system-wide measurements such as gene expression with networks of protein-protein interactions and transcription factor binding revealed critical insights into cellular behavior. However, the potential of systems biology approaches is limited by difficulties in integrating metabolic measurements across the functional levels of the cell despite their being most closely linked to cellu  ...[more]

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