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Microarray analysis of gene expression in HDAC9-knockdown macrophages.

ABSTRACT: To investigate the role of HDAC9 in innate immnue, we measured the gene expression profile in HDAC9-knockdown macrophages in the absence of innate stimuli by gene-chip in order to find wherther HDAC9 knockdown affect the innate immune factor. We found knockdown of HDAC9 barely affected transcription of innate immnue signaling transducers. HDAC9, as a class IIa HDAC, shuttle between the nucleus and cytoplasm. Here we showed that high expression of cytoplasmic HDAC9, maybe play a Post-translational regulation role in macrophages.

ORGANISM(S): Mus musculus

PROVIDER: GSE74749 | GEO | 2016/11/06

SECONDARY ACCESSION(S): PRJNA301405

REPOSITORIES: GEO

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