Dataset Information
A cis-regulatory element controls HDAC9 expression to fine-tune inflammasome-dependent chronic inflammation
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Ignasi Forne
LAB HEAD: Prof. Dr. Martin Dichgans
PROVIDER: PXD042078 | Pride | 2025-07-10
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Groups.txt | Txt | |||
| Ref7473_YA_01_20220329.raw | Raw | |||
| Ref7473_YA_02_20220329.raw | Raw | |||
| Ref7473_YA_03_20220329.raw | Raw | |||
| Ref7473_YA_04_20220329.raw | Raw |
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Publications
A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis.
Immunity 20250128 3
Common genetic variants in a conserved cis-regulatory element (CRE) at histone deacetylase (HDAC)9 are a major risk factor for cardiovascular disease, including stroke and coronary artery disease. Given the consistency of this association and its proinflammatory properties, we examined the mechanisms whereby HDAC9 regulates vascular inflammation. HDAC9 bound and mediated deacetylation of NLRP3 in the NACHT and LRR domains leading to inflammasome activation and lytic cell death. Targeted deletion ...[more]