Transcriptomics,Genomics

Dataset Information

87

The metabolic response to a high-fat diet reveals obesity-prone and -resistant phenotypes in mice with distinct mRNA-seq transcriptome profiles


ABSTRACT: We investigated phenotypic differences underpinning obesity susceptibility or resistance based on metabolic and transcriptional profiling in C57BL/6J mice fed a high-fat diet (HFD) Overall design: Total RNA of epididymal adipose tissues and liver was obtained from normal diet, high-fat diet-fed mice and mRNA expression-associated with lipid, and glucose metabolism was measured.

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

SUBMITTER: Ji-Young Choi 

PROVIDER: GSE74804 | GEO | 2017-11-08

SECONDARY ACCESSION(S): PRJNA301586

REPOSITORIES: GEO

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Publications

The metabolic response to a high-fat diet reveals obesity-prone and -resistant phenotypes in mice with distinct mRNA-seq transcriptome profiles.

Choi J-Y JY   McGregor R A RA   Kwon E-Y EY   Kim Y J YJ   Han Y Y   Park J H Y JH   Lee K W KW   Kim S-J SJ   Kim J J   Yun J W JW   Choi M-S MS  

International journal of obesity (2005) 20160505 9


The aim of this study was to explore the phenotypic differences underpinning obesity susceptibility or resistance based on the metabolic and transcriptional profiling of C57BL/6J mice fed a high-fat diet (HFD).The mice were fed either a normal diet or HFD for 12 weeks. After 6 weeks, the mice on HFD were classified as either obesity-prone (OP) or obesity-resistant (OR) depending on the body weight gain.Lipid profiles from plasma and liver significantly improved in OR mice relative to the OP grou  ...[more]

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