Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 1000 (Homo sapiens)
SUBMITTER: Shan Lin
PROVIDER: GSE76978 | GEO | 2016-11-23
SECONDARY ACCESSION(S): PRJNA309171
REPOSITORIES: GEO
Lin Shan S Luo Roger T RT Ptasinska Anetta A Kerry Jon J Assi Salam A SA Wunderlich Mark M Imamura Toshihiko T Kaberlein Joseph J JJ Rayes Ahmad A Althoff Mark J MJ Anastasi John J O'Brien Maureen M MM Meetei Amom Ruhikanta AR Milne Thomas A TA Bonifer Constanze C Mulloy James C JC Thirman Michael J MJ
Cancer cell 20161101 5
The t(4;11)(q21;q23) fuses mixed-lineage leukemia (MLL) to AF4, the most common MLL-fusion partner. Here we show that MLL fused to murine Af4, highly conserved with human AF4, produces high-titer retrovirus permitting efficient transduction of human CD34<sup>+</sup> cells, thereby generating a model of t(4;11) pro-B acute lymphoblastic leukemia (ALL) that fully recapitulates the immunophenotypic and molecular aspects of the disease. MLL-Af4 induces a B ALL distinct from MLL-AF9 through different ...[more]