Transcriptomics,Genomics

Dataset Information

34

Rapid Inflammasome Activation Following Mucosal SIV infection of Rhesus Monkeys


ABSTRACT: The purpose of this study was to evaluated the kinetics of virus dissemination to distal tissues and the initial innate and adaptive host immune responses following intravaginal SIV infection of rhesus monkeys. Overall design: We performed comprehensive serial necropsies in rhesus monkeys (M. mulatta) on day 0, day 1, day 3, day 7 and day 10 following intravaginal inoculation of 5x104 TCID50 SIVmac251, measured viral RNA, and performed transcriptomic analysis to measure gene expression changes that correlate with virus spread. note: Grouped different sections of a tissue based on similar transcriptomic profiles; example: FRT = vagina+uterus+cervix

INSTRUMENT(S): Illumina HumanHT-12 V4.0 expression beadchip

SUBMITTER: Dan Barouch  

PROVIDER: GSE80013 | GEO | 2016-05-01

SECONDARY ACCESSION(S): PRJNA317627

REPOSITORIES: GEO

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