Transcriptomics,Genomics

Dataset Information

40

Phenotypically-anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish


ABSTRACT: We employed whole-genome microarray expression profiling in 48 hpf zebrafish to better understand the mechanism of action of the antimicrobial agent, triclosan (TCS) Overall design: TCS-induced transcriptional changes was measured in 48 hpf embryos exposed to 0 or 7.37 uM TCS from 6-48 hpf. Four biological replicates of 8 pooled whole embryos were used for each treatment

INSTRUMENT(S): Agilent-069507 ArrayXS_Danio_rerio_V1 (Probe Name version)

SUBMITTER: Robert L Tanguay  

PROVIDER: GSE80955 | GEO | 2016-10-31

SECONDARY ACCESSION(S): PRJNA320110

REPOSITORIES: GEO

altmetric image

Publications

Phenotypically anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish.

Haggard Derik E DE   Noyes Pamela D PD   Waters Katrina M KM   Tanguay Robert L RL  

Toxicology and applied pharmacology 20160815


Triclosan (TCS) is an antimicrobial agent commonly found in a variety of personal care products and cosmetics. TCS readily enters the environment through wastewater and is detected in human plasma, urine, and breast milk due to its widespread use. Studies have implicated TCS as a disruptor of thyroid and estrogen signaling; therefore, research examining the developmental effects of TCS is warranted. In this study, we used embryonic zebrafish to investigate the developmental toxicity and potentia  ...[more]

Similar Datasets

| GSE89321 | GEO
2010-05-19 | E-GEOD-16189 | ArrayExpress
2010-05-19 | GSE16189 | GEO
2016-02-29 | E-GEOD-69275 | ArrayExpress
| GSE87398 | GEO
2010-10-08 | E-GEOD-15059 | ArrayExpress
2020-06-04 | PXD018347 | Pride
2013-10-15 | E-GEOD-39343 | ArrayExpress
2009-08-20 | GSE15059 | GEO
| GSE89780 | GEO