Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Human Gut Metagenome
TISSUE(S): Feces
SUBMITTER: Morgan Walker
LAB HEAD: Matthew R. Redinbo
PROVIDER: PXD025887 | Pride | 2021-11-04
REPOSITORIES: Pride
Zhang Jianan J Walker Morgan E ME Sanidad Katherine Z KZ Zhang Hongna H Liang Yanshan Y Zhao Ermin E Chacon-Vargas Katherine K Yeliseyev Vladimir V Parsonnet Julie J Haggerty Thomas D TD Wang Guangqiang G Simpson Joshua B JB Jariwala Parth B PB Beaty Violet V VV Yang Jun J Yang Haixia H Panigrahy Anand A Minter Lisa M LM Kim Daeyoung D Gibbons John G JG Liu LinShu L Li Zhengze Z Xiao Hang H Borlandelli Valentina V Overkleeft Hermen S HS Cloer Erica W EW Major Michael B MB Goldfarb Dennis D Cai Zongwei Z Redinbo Matthew R MR Zhang Guodong G
Nature communications 20220110 1
Emerging research supports that triclosan (TCS), an antimicrobial agent found in thousands of consumer products, exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models. While the intestinal toxicities of TCS require the presence of gut microbiota, the molecular mechanisms involved have not been defined. Here we show that intestinal commensal microbes mediate metabolic activation of TCS in the colon and drive its gut toxicology. Using a range of in vitro, ex vivo, an ...[more]