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Genome-wide methylation analysis reveals methylation subtypes of Barrett's Esophagus and Esophageal Adenocarcinoma

ABSTRACT: Methylation-based subtypes were identified in nondysplastic Barrett's Esophagus (BE) from BE-only patients (n=62) and Esophageal Adenocarcinoma (n=23) using RPMM-based clustering on methylation data at probes with the most variant Beta-values on the HM450 platform. Samples in these methylation-based subtypes were further identified in the TCGA EAC dataset, and subtypes were characterized using integrated analysis of methylation, sequencing, and expression data.

ORGANISM(S): Homo sapiens

PROVIDER: GSE81334 | GEO | 2019/01/01

REPOSITORIES: GEO

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