Zebrafish response to Mycobacterium marinum infection (Affymetrix series)

ABSTRACT: Mycobacteria infect macrophages that aggregate with additional macrophages and lymphocytes to form granulomas. We have used a functional genomics approach to identify immune response genes expressed during granuloma formation in Mycobacterium marinum-infected transparent zebrafish larvae where individual infection steps can be viewed in real time. We assessed RNA expression profiles from zebrafish larvae that were either infected with Mycobacterium marinum, mock-infected, or uninfected. Zebrafish infections were performed at 1 day post-fertilization (dpf), and samples were derived from pools of 6dpf zebrafish larvae. Keywords: host response to infection

ORGANISM(S): Danio rerio

PROVIDER: GSE8327 | GEO | 2008/01/01

SECONDARY ACCESSION(S): PRJNA101317

REPOSITORIES: GEO