Genomics

Dataset Information

33

Role of H4K8ac in P. falciparum life cycle [ChIP]


ABSTRACT: Study of chromatin changes of P. falciparum in response to changes in the levels of histone H4 acetylations especially H4K8ac using chromatin immunoprecipitation coupled to microarray chip (ChIP-on-chip) Overall design: ChIP-on-chip of P. falciparum intraerythrocyic life cycle upon hyper or hypo acetylated Histone H4 achieved by treating the cells with HDAC inhibitors or mutating the lysine residues respectively

INSTRUMENT(S): ZB/SBS-NTU Plasmodium falciparum 3D7 IGR+ORF 16.8K v1.0

SUBMITTER: Archana P Gupta  

PROVIDER: GSE84083 | GEO | 2017-07-25

SECONDARY ACCESSION(S): PRJNA328407

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE84083_Normalized_data_with_all_controls_ChIP.txt.gz Txt
GSE84083_RAW.tar Raw
filelist.txt Txt
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Publications

Histone 4 lysine 8 acetylation regulates proliferation and host-pathogen interaction in Plasmodium falciparum.

Gupta Archana P AP   Zhu Lei L   Tripathi Jaishree J   Kucharski Michal M   Patra Alok A   Bozdech Zbynek Z  

Epigenetics & chromatin 20170822 1


<h4>Background</h4>The dynamics of histone modifications in Plasmodium falciparum indicates the existence of unique mechanisms that link epigenetic factors with transcription. Here, we studied the impact of acetylated histone code on transcriptional regulation during the intraerythrocytic developmental cycle (IDC) of P. falciparum.<h4>Results</h4>Using a dominant-negative transgenic approach, we showed that acetylations of histone H4 play a direct role in transcription. Specifically, these histo  ...[more]

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