Transcriptomics,Genomics

Dataset Information

155

A penicillin-binding protein inhibits selection of colistin-resistant, lipooligosaccharide-deficient Acinetobacter baumannii


ABSTRACT: We report the transcriptional expression from wild type, a ponA mutant, and lipooligosaccharide-deficient A. baumannii in order to understand the cellular changes after inactivation of lipid A biosynthesis. Among all strains, genes in the Localization Of Lipoprotein (Lol) transport pathway were upregulated. This study provides a framework to understand how some Acinetobacter baumannii strains can survive without lipid A and lipopolysaccharide/lipooligosaccharide. Overall design: Examination of the global transcriptome in four different A. baumannii strains.

INSTRUMENT(S): Illumina HiSeq 4000 (Acinetobacter baumannii)

SUBMITTER: Joseph Michael Boll  

PROVIDER: GSE84282 | GEO | 2016-09-28

SECONDARY ACCESSION(S): PRJNA328520

REPOSITORIES: GEO

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Publications

A penicillin-binding protein inhibits selection of colistin-resistant, lipooligosaccharide-deficient Acinetobacter baumannii.

Boll Joseph M JM   Crofts Alexander A AA   Peters Katharina K   Cattoir Vincent V   Vollmer Waldemar W   Davies Bryan W BW   Trent M Stephen MS  

Proceedings of the National Academy of Sciences of the United States of America 20160928 41


The Gram-negative bacterial outer membrane fortifies the cell against environmental toxins including antibiotics. Unique glycolipids called lipopolysaccharide/lipooligosaccharide (LPS/LOS) are enriched in the cell-surface monolayer of the outer membrane and promote antimicrobial resistance. Colistin, which targets the lipid A domain of LPS/LOS to lyse the cell, is the last-line treatment for multidrug-resistant Gram-negative infections. Lipid A is essential for the survival of most Gram-negative  ...[more]

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