Transcriptomics,Genomics

Dataset Information

44

Transcriptional Dynamics of Cultured Human Villous Cytotrophoblasts


ABSTRACT: Transcriptomic characterization of cultured primary human cytrophoblasts (2nd trimester) undergoing differentiation/invasion in vitro. Overall design: Transcriptome of human villous cytotrophoblasts at 0h (following isolation) or 3, 15, or 39h after plating on Matrigel (in vitro). Sample processing and hybridization was performed by the UCSF Gladstone Institute

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

SUBMITTER: Joshua F Robinson  

PROVIDER: GSE86171 | GEO | 2017-03-31

SECONDARY ACCESSION(S): PRJNA340445

REPOSITORIES: GEO

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Publications

Transcriptional Dynamics of Cultured Human Villous Cytotrophoblasts.

Robinson Joshua F JF   Kapidzic Mirhan M   Gormley Matthew M   Ona Katherine K   Dent Terrence T   Seifikar Helia H   Hamilton Emily G EG   Fisher Susan J SJ  

Endocrinology 20170601 6


During human pregnancy, cytotrophoblasts (CTBs) play key roles in uterine invasion, vascular remodeling, and anchoring of the feto-placental unit. Due to the challenges associated with studying human placentation in utero, cultured primary villous CTBs are used as a model of the differentiation pathway that leads to invasion of the uterine wall. In vitro, CTBs emulate in vivo cell behaviors, such as migration, aggregation, and substrate penetration. Although some of the molecular features relate  ...[more]

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