Dataset Information


RNA sequencing quantitative analysis of RNA editing levels in ADAR1, ADAR2, AIMP2 overexpression and wild type HEK293 cells

ABSTRACT: We overexpressed ADAR1, ADAR2 and AIMP2 in HEK293 cells and examined editing using RNA-seq. Overall design: mRNA profiles of wild type (WT) and ADAR1, ADAR2 and AIMP2 overexpression HEK293 cells were generated by deep sequencing using Illumina HiSeq 2000.

INSTRUMENT(S): Illumina HiSeq 2000 (Homo sapiens)

SUBMITTER: Jin Billy Li  

PROVIDER: GSE87198 | GEO | 2017-10-01



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Adenosine-to-inosine (A-to-I) RNA editing is a conserved post-transcriptional mechanism mediated by ADAR enzymes that diversifies the transcriptome by altering selected nucleotides in RNA molecules. Although many editing sites have recently been discovered, the extent to which most sites are edited and how the editing is regulated in different biological contexts are not fully understood. Here we report dynamic spatiotemporal patterns and new regulators of RNA editing, discovered through an exte  ...[more]

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