Transcriptomics,Genomics

Dataset Information

141

Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer


ABSTRACT: Chronic activation of Notch1 synergizes with multiple oncogenic pathways altered in early prostate cancer to promote the development of prostate adenocarcinoma. Expression profiling revealed that these tumors display features of epithelial-to-mesenchymal transition, a cellular state associated with increased tumor aggressiveness.Tumors driven by Notch1 intracellular domain in combination with multiple pathways altered in prostate cancer are metastatic and resistant to androgen deprivation. Overall design: Mouse prostate tumors initiated by the combination of NICD1/kRasG12D, NICD1/myrAKT, or NICD/Myc and normal mouse prostates were subjected to high-throughput RNA-sequencing and differential gene-expression analysis

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Tanya Stoyanova  

PROVIDER: GSE87448 | GEO | 2016-12-07

SECONDARY ACCESSION(S): PRJNA344781

REPOSITORIES: GEO

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Publications


Metastatic castration-resistant prostate cancer (CRPC) is the primary cause of prostate cancer-specific mortality. Defining new mechanisms that can predict recurrence and drive lethal CRPC is critical. Here, we demonstrate that localized high-risk prostate cancer and metastatic CRPC, but not benign prostate tissues or low/intermediate-risk prostate cancer, express high levels of nuclear Notch homolog 1, translocation-associated (Notch1) receptor intracellular domain. Chronic activation of Notch1  ...[more]

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