Transcriptomics,Genomics

Dataset Information

84

RNA-Seq based comparison of Staphylococcus aureus strains resistent and sensitive to MT02


ABSTRACT: A MT02 sensitive and resistant strain of Staphylococcus LAC USA300 JE2 were exposed to MT02. From those cell RNA was extracted and anylsed by RNA-Seq Overall design: Comparison of the expression profiles of Staphylococcus aureus strains resistent and sensitive to MT02

INSTRUMENT(S): Illumina Genome Analyzer IIx (Staphylococcus aureus)

SUBMITTER: Konrad U. Förstner  

PROVIDER: GSE87572 | GEO | 2017-11-05

SECONDARY ACCESSION(S): PRJNA345213

REPOSITORIES: GEO

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Publications

A Novel Mechanism of Inactivating Antibacterial Nitro Compounds in the Human Pathogen Staphylococcus aureus by Overexpression of a NADH-Dependent Flavin Nitroreductase.

El-Hossary Ebaa M EM   Förstner Konrad U KU   François Patrice P   Baud Damien D   Streker Karin K   Schrenzel Jacques J   Ohlsen Knut K   Holzgrabe Ulrike U  

Antimicrobial agents and chemotherapy 20180125 2


Recently, the nitro-substituted bisquaternary bisnaphthalimides were reported to have substantial anti-infective activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Here, we selected resistant S. aureus clones by cultivation in increasing concentrations of the most active compound, MT02. Interestingly, MT02-resistant variants induced a diffusible red color of the broth. Chromatographic and spectroscopic investigations revealed a stepwise reducti  ...[more]

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