Transcriptomics,Genomics

Dataset Information

47

A global transcriptome analysis of skin wounds of diabetic mice (db/db) treated with miR-132 or control mimics


ABSTRACT: MiR-132 is one of the most upregulated miRNAs in human skin wounds at the inflammatory phase of healing. MiR-132 inhibits inflammation but promotes growth of epidermal keratinocytes, indicating that it may facilitate the inflammatory-proliferative phase transition during wound repair. Following this line of research, here we evaluated the therapeutic potential of miR-132 in chronic wound using mouse in vivo wound model. We performed a global transcriptome analysis of skin wounds of leptin receptor-deficient (db/db) mice treated with miR-132 or control mimics. Db/db mouse has been used as a type 2 diabetic model with impaired wound healing capacity. Overall design: Expression profiling of skin wounds of db/db mice locally treated with miR-132 or control mimics for 6 days (5 mice in each group) was performed using Affymetrix mouse Clariom™ D assay.

INSTRUMENT(S): [MTA-1_0] Affymetrix Mouse Transcriptome Array 1.0 [transcript (gene) CSV version]

SUBMITTER: Ning Xu 

PROVIDER: GSE92409 | GEO | 2017-02-01

SECONDARY ACCESSION(S): PRJNA357490

REPOSITORIES: GEO

Similar Datasets

| GSE61139 | GEO
2017-01-01 | S-EPMC5249255 | BioStudies
2015-01-01 | S-EPMC4679295 | BioStudies
| GSE87436 | GEO
2014-01-01 | S-EPMC4112003 | BioStudies
2020-01-01 | S-EPMC7283391 | BioStudies
1000-01-01 | S-EPMC4764471 | BioStudies
1000-01-01 | S-EPMC4901296 | BioStudies
2016-01-01 | S-EPMC6208129 | BioStudies
2018-01-01 | S-EPMC6180296 | BioStudies