Dataset Information


Distinct Sets Of Genes Representing Overlapping Biological Functions Are Altered By Intrinsic Properties Of Carbon Nanomaterials In Vitro And In Vivo [mouse]

ABSTRACT: Six different carbon nanomaterials (CNM) administered by oropharyngeal aspiration to C57BL/6 mice (on 4 consecutive days with 10ug of CNM per day in PBS, sacrificed on 5th day) and to differentiated THP-1 cells in culture (6 hour and 24 hour, with 100ug of CNM /ml of medium) Overall design: C57BL/6 mice were exposed to six different CNM by oropharyngeal aspiration (10 μg/day in 50μl of PBS) once per day for 4 consecutive days. Bronchoalveolar lavage and lung tissue samples were collected, histological sections analyzed and mRNA expression profiles were determined by Agilent microarray. Vehicle treated (PBS) was used as Controls. Two mRNA samples from same group were pooled as one sample.

INSTRUMENT(S): Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Feature Number version)

SUBMITTER: Dario Greco  

PROVIDER: GSE92900 | GEO | 2017-07-18



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Network Analysis Reveals Similar Transcriptomic Responses to Intrinsic Properties of Carbon Nanomaterials in Vitro and in Vivo.

Kinaret Pia P   Marwah Veer V   Fortino Vittorio V   Ilves Marit M   Wolff Henrik H   Ruokolainen Lasse L   Auvinen Petri P   Savolainen Kai K   Alenius Harri H   Greco Dario D  

ACS nano 20170411 4

Understanding the complex molecular alterations related to engineered nanomaterial (ENM) exposure is essential for carrying out toxicity assessment. Current experimental paradigms rely on both in vitro and in vivo exposure setups that often are difficult to compare, resulting in questioning the real efficacy of cell models to mimic more complex exposure scenarios at the organism level. Here, we have systematically investigated transcriptomic responses of the THP-1 macrophage cell line and lung t  ...[more]

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