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Conditioned Taste Aversion experiment

ABSTRACT: Conditioned Taste Aversion experiment Keywords: other

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE930 | GEO | 2004/12/22

SECONDARY ACCESSION(S): PRJNA87959

REPOSITORIES: GEO

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Conditioned Taste Aversion experiment

Project description:Conditioned Taste Aversion experiment

2010-05-27 | E-GEOD-930 | biostudies-arrayexpress

Rattus norvegicus

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Cell type-specific RNA-seq to profile transcriptional changes in sorted BLA projection neurons during conditioned taste aversion learning

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microarray of Amygdala of CTA rats

Project description:Feeding is an important activity for all animals providing nutrients essential for survival and reproduction. Not surprisingly, learning plays a critical role in feeding behavior through the establishment and strengthening of food preferences and aversions. That is, the integration of taste and post ingestive visceral signals in the brain results in memorial representations about the consequences associated with ingesting a particular food. For example, when ingestion of a food is followed by negative gastrointestinal consequences (e.g. nausea, sickness, or vomiting), the animal develops a conditioned taste aversion (CTA), which produces a switch from acceptance to avoidance of that and any like tasting stimulus. Despite recent advances in understanding CTA responsive intracellular signaling pathways in the amygdala, little is known about any long-term regulation of target gene expression following CTA memory consolidation and retrieval. The present study utilized oligo-nucleotide microarray to understand the genes and networks involved in Conditional Taste Aversion Behavior.

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Transcription profiling of Drosophila melanogaster taste tissue

Project description:To uncover novel molecules involved in taste detection, we performed a microarray-based screen for genes enriched in taste neurons. Proboscis RNA from flies homozygous for a recessive poxn null mutation was compared to RNA from heterozygous controls. Poxn mutants have a transformation of labellar gustatory chemosensory bristles into mechanosensory bristles and therefore lack most or all taste neurons. Experiment Overall Design: Proboscises of poxn70 homozygous mutant and poxn70 heterozygous mutant males (8-18 days post eclosure) were dissected, and total RNA was harvested in Trizol according to standard trizol protocol. Samples for each microarray were prepared from 164-280 proboscises. We performed 3 biological replicates for each genotype.

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