Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression analysis of Bacillus anthracis Sterne wild-type and deltaClpX mutant strains

ABSTRACT: Investigation of whole genome expression level changes in Bacillus anthracis Sterne deltaClpX mutant compared to the wild-type strain after growth in nutrient rich media. The deltaClpX mutant used in this study is described in McGillivray et al. 2009. ClpX Protease Contributes to Antimicrobial Peptide Resistance and Virulence Phenotypes of Bacillus anthracis. Journal of Innate Immunity 1(5): 494-506.

ORGANISM(S): Bacillus anthracis str. Sterne

PROVIDER: GSE94398 | GEO | 2018/02/14

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Bacillus anthracis Stern 34F2 sporulation

Project description:Timecourse from log phase growth to sporulation in Bacillus anthracis Stern 34F2 Keywords: time-course

2004-01-08 | GSE840 | GEO

Bacillus anthracis Stern 34F2 sporulation

Project description:Timecourse from log phase growth to sporulation in Bacillus anthracis Stern 34F2

2010-06-09 | E-GEOD-840 | biostudies-arrayexpress

Comparative Genomics of Bacillus cereus and Bacillus anthracis

Project description:The aim of the study was to carry out a CGH study utilizing a set of 39 diverse Bacillus isolates. Thirty four B. cereus and five B. anthracis strains and isolates were chosen so as to represent different lineages based on previous characterizations, including MLEE and MLST (Helgason, Okstad et al. 2000; Helgason, Tourasse et al. 2004). They represent the spectrum of B. cereus phenotypic diversity by including soil, dairy and periodontal isolates in addition to virulent B. anthracis strains.

2009-11-25 | GSE19068 | GEO

Bacillus anthracis gene expression upon plantazolicin and Me2-Arg-Az5

Project description:Subinhibitory concentrations of compound used to assess their influence on the gene expression profile of Bacillus anthracis.

2017-02-28 | GSE73343 | GEO

Transcriptome of Bacillus anthracis lethal toxin (LT)-intoxicated HUVECs monolayers

Project description:We have analyzed the variation of transcriptome of HUVECs intoxicated by the lethal toxin of Bacillus anthracis at 4 and 8 hours

2010-01-26 | GSE12131 | GEO

Direct regulons of the master virulence regulator AtxA of Bacillus anthracis

Project description:AtxA, the master virulence regulator of Bacillus anthracis, regulates the expression of three toxins that are required for the pathogenicity of Bacillus anthracis. Recent transcriptome analyses also showed that AtxA affects a large number of genes on both chromosome and plasmid, suggesting its role as a global regulator. Its mechanism of gene regulation nor binding target in vivo was, however, not well understood. In this work, we conducted ChIP-seq for cataloging binding sites of AtxA in vivo and Cappable-seq for catalogging the transcription start sites on the B. anthracis genome. For detected regulons, single knockout strains were constructed and RNA-seq was conducted for each strain.

2021-06-28 | GSE167871 | GEO

Transcription profiling of Bacillus anthracis Sterne during iron starvation

Project description:Effects of iron starvation on the transcriptional profile of Bacillus anthracis

2010-07-22 | E-MEXP-2272 | biostudies-arrayexpress

Identification of Bacillus anthracis genes differentially expressed in human serum

Project description:Bacillus anthracis causes anthrax infections in mammals. Large-scale mortality resulting from the intentional release of B. anthracis spores represents a potential bioterrorism threat. Inhalational anthrax almost invariably proceeds to fatal systemic infection, characterized by massive bacteremia. A better understanding of host-pathogen interactions is urgently needed for effective treatment of this lethal disease. However, virulence mechanisms used by B. anthracis to survive and multiply in human blood are not completely understood. Identification of genes that are differentially expressed during the growth of B. anthracis in human serum can elucidate how this pathogen successfully colonizes the bloodstream. We compared the transcriptional profile of B. anthracis growing in heat-inactivated human serum to that in LB medium. Genes involved in the biosynthesis of purines, certain amino acids and riboflavin and lipid metabolism, genes encoding ABC transporters, respiratory enzymes and several genes with hypothetical function were identified as being upregulated during growth in serum.

2022-12-01 | GSE97567 | GEO

Whole Genome Expression Profile of Human Peripheral Blood Mononuclear Cells Exposed to Bacillus anthracis in vitro

Project description:hole Genome Expression Profile of Human Peripheral Blood Mononuclear cells Exposed to Bacillus anthracis in vitro. Peripheral blood mononuclear cells exposed to a 1 MOI (multiplicity of infection pathogenic) of the B. anhracis spores. Human Peripheral Blood Mononuclear cells Exposed to Bacillus anthracis in vitro

2010-05-19 | E-GEOD-15068 | biostudies-arrayexpress

Transcription profiling of human NB4 cells treated with lethal Bacillus anthracis toxin

Project description:Bacillus anthracis lethal toxin (LT) exposure on NB-4 cells Experiment Overall Design: color-swap dye-reversal

2008-06-14 | E-GEOD-5966 | biostudies-arrayexpress