Transcriptomics,Genomics

Dataset Information

34

Expression analysis of Bacillus anthracis Sterne wild-type and deltaClpX mutant strains


ABSTRACT: Investigation of whole genome expression level changes in Bacillus anthracis Sterne deltaClpX mutant compared to the wild-type strain after growth in nutrient rich media. The deltaClpX mutant used in this study is described in McGillivray et al. 2009. ClpX Protease Contributes to Antimicrobial Peptide Resistance and Virulence Phenotypes of Bacillus anthracis. Journal of Innate Immunity 1(5): 494-506. Overall design: A six chip study using total RNA recovered from three separate cultures of the wild-type Bacillus anthracis Sterne strain and three separate cultures of the deltaClpX mutant strain. Each chip measures the expression level of 5287 chromosomal genes from Bacillus anthracis Sterne.

INSTRUMENT(S): Roche NimbleGen Bacillus anthracis Sterne 385K Gene Expression Microarray [2006-07-27_TI260799_60mer]

SUBMITTER: Shauna McGillivray  

PROVIDER: GSE94398 | GEO | 2018-02-14

REPOSITORIES: GEO

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Publications

Transcriptional profiling of the clpX mutant in Bacillus anthracis reveals regulatory connection with the lrgAB operon.

Claunch Kevin M KM   Bush Madeline M   Evans Christopher R CR   Malmquist Jacob A JA   Hale Matthew C MC   McGillivray Shauna M SM  

Microbiology (Reading, England) 20180223 4


ClpX functions as either an independent chaperone or a component of the ClpXP protease, a conserved intracellular protease that acts as a global regulator in the bacterial cell by degrading regulatory proteins, stress response proteins and rate-limiting enzymes. Previously, we found that loss of clpX in Bacillus anthracis Sterne leads to increased susceptibility to antimicrobial agents that target the cell envelope. The aim of this study was to identify genes within the regulatory network of clp  ...[more]

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