Dataset Information


Bacillus anthracis gene expression upon plantazolicin and Me2-Arg-Az5

ABSTRACT: Subinhibitory concentrations of compound used to assess their influence on the gene expression profile of Bacillus anthracis. Overall design: Bacillus anthracis cells were treated with 0.25X MIC of compound (Me2-Arg-Az5, plantazolicin) for 10 min. RNA was isolated, sequenced, and analyzed using Rockhopper.

INSTRUMENT(S): Illumina HiSeq 2000 (Bacillus anthracis str. Sterne)

SUBMITTER: Douglas A Mitchell  

PROVIDER: GSE73343 | GEO | 2017-02-28



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Plantazolicin is an ultra-narrow spectrum antibiotic that targets the Bacillus anthracis membrane.

Molohon Katie J KJ   Blair Patricia M PM   Park Seongjin S   Doroghazi James R JR   Maxson Tucker T   Hershfield Jeremy R JR   Flatt Kristen M KM   Schroeder Nathan E NE   Ha Taekjip T   Mitchell Douglas A DA  

ACS infectious diseases 20151223 3

Plantazolicin (PZN) is a ribosomally synthesized and post-translationally modified natural product from Bacillus methylotrophicus FZB42 and Bacillus pumilus. Extensive tailoring to twelve of the fourteen amino acid residues in the mature natural product endows PZN with not only a rigid, polyheterocyclic structure, but also antibacterial activity. Here we report a remarkably discriminatory activity of PZN toward Bacillus anthracis, which rivals a previously-described gamma (γ) phage lysis assay i  ...[more]

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