Dataset Information


Single cell RNA expression of mouse embryonic basal forebrain

ABSTRACT: Single-cell RNA-Seq RNA from medial ganglionic eminence at E11.5, E13.5, E15.5 or E17.5. The ID of this project in Genentech's ExpressionPlot database is PRJ0007389 Overall design: Single-cell RNA-Seq from medial ganglionic eminence at E11.5, E13.5, E15.5 or E17.5.

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

SUBMITTER: Brad A Friedman  

PROVIDER: GSE94641 | GEO | 2017-03-02



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Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types.

Chen Ying-Jiun J YJ   Friedman Brad A BA   Ha Connie C   Durinck Steffen S   Liu Jinfeng J   Rubenstein John L JL   Seshagiri Somasekar S   Modrusan Zora Z  

Scientific reports 20170331

Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, but the mechanism generating their diversity remains elusive. We performed single-cell RNA sequencing on the mouse embryonic medial ganglionic eminence (MGE), the major birthplace for CINs, and on MGE-like cells differentiated from embryonic stem cells. Two distinct cell types were identified as proliferating neural progenitors and immature neurons, both of which comprised sub-populations. Although lineage developme  ...[more]

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