Genomics

Dataset Information

0

Platelet-derived growth factor receptor signaling is required for postnatal tendon growth


ABSTRACT: Platelet-derived growth factor receptor (PDGFR) signaling plays an important role in the embryonic formation of many different tissues. There is a family of PDGF isoforms which signal through the PDGF receptors α (PDGFRα) and β (PDGFRβ). PDGF regulates many key cellular processes of mesenchymal cell function including proliferation, differentiation, migration and extracellular matrix (ECM) synthesis. While PDGF has been used to enhance flexor tendon healing in vivo, its role in postnatal tendon growth has remained largely unexplored. To determine the importance of PDGFR signaling in postnatal tendon growth, we performed pharmacological blockade of PDGFRα and PDGFRβ, and then induced tendon growth via mechanical overload using the hindlimb synergist ablation model. Our hypothesis was that inhibition of PDGFR signaling will restrict normal growth of tendon tissue in response to mechanical loading.

ORGANISM(S): Mus musculus

PROVIDER: GSE95794 | GEO | 2017/03/08

SECONDARY ACCESSION(S): PRJNA378415

REPOSITORIES: GEO

Similar Datasets

2016-10-25 | GSE89111 | GEO
2021-05-21 | PXD024162 | Pride
2005-11-09 | E-SMDB-3543 | biostudies-arrayexpress
2006-01-27 | E-GEOD-4096 | biostudies-arrayexpress
| PRJNA95253 | ENA
2006-01-28 | GSE4096 | GEO
2023-06-19 | MSV000092208 | MassIVE
2018-02-01 | GSE107047 | GEO
2021-02-08 | GSE156157 | GEO
2011-02-28 | E-GEOD-27181 | biostudies-arrayexpress