Transcriptomics,Genomics

Dataset Information

45

Disrupted miRNA expression in HAND


ABSTRACT: The role of miRNA disregulation in the development of HIV associated Neurocognitive Disorder was assessed in post mortem cerebral tissue. We used microarrays to compare the expression of miRNAs in patient with HIV showing no neurological complications to those with HAND in the presence or absence of active HIV encephalitis Overall design: 30 post mortem human neocortex specimens were obtained from the NNTC, several of which had previously been examined using mRNA arrays, and total RNA was extracted, labelled and hybridized to Affymetrix miRNA 3.0 chips to assess specific changes in miRNA expression to provide clues to host genes with altered regulation in HAND.

INSTRUMENT(S): [miRNA-3] Affymetrix Multispecies miRNA-3 Array

SUBMITTER: William George Branton  

PROVIDER: GSE97611 | GEO | 2017-04-11

SECONDARY ACCESSION(S): PRJNA382423

REPOSITORIES: GEO

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Publications

MicroRNAs upregulated during HIV infection target peroxisome biogenesis factors: Implications for virus biology, disease mechanisms and neuropathology.

Xu Zaikun Z   Asahchop Eugene L EL   Branton William G WG   Gelman Benjamin B BB   Power Christopher C   Hobman Tom C TC  

PLoS pathogens 20170608 6


HIV-associated neurocognitive disorders (HAND) represent a spectrum neurological syndrome that affects up to 25% of patients with HIV/AIDS. Multiple pathogenic mechanisms contribute to the development of HAND symptoms including chronic neuroinflammation and neurodegeneration. Among the factors linked to development of HAND is altered expression of host cell microRNAs (miRNAs) in brain. Here, we examined brain miRNA profiles among HIV/AIDS patients with and without HAND. Our analyses revealed dif  ...[more]

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