Metabolomics

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GNPS-Passive accumulation of alkaloids in non-toxic frogs challenges paradigms of the origins of acquired chemical defenses


ABSTRACT: Paper Title: Passive accumulation of alkaloids in non-toxic frogs challenges paradigms of the origins of acquired chemical defenses. Author List; Rebecca D Tarvin, Jeffrey L Coleman, David A Donoso, Mileidy Betancourth-Cundar, Karem Lopez-Hervas, Kimberly S Gleason, J Ryan Sanders, Jacqueline M Smith, Santiago R Ron, Juan C Santos, Brian E Sedio, David C Cannatella, Richard Fitch RAW files used for alkaloid identification in crude skin extracts. Citation: eLife August 2, 2024 DOI: 10.7554/eLife.100011.1

INSTRUMENT(S): ITQ 1100

ORGANISM(S): Multiple Frog Species

SUBMITTER: Rebecca D. Tarvin  

PROVIDER: MSV000095866 | GNPS |

REPOSITORIES: GNPS

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Passive accumulation of alkaloids in inconspicuously colored frogs refines the evolutionary paradigm of acquired chemical defenses.

Tarvin Rebecca D RD   Coleman Jeffrey L JL   Donoso David A DA   Betancourth-Cundar Mileidy M   López-Hervas Karem K   Gleason Kimberly S KS   Sanders J Ryan JR   Smith Jacqueline M JM   Ron Santiago R SR   Santos Juan C JC   Sedio Brian E BE   Cannatella David C DC   Fitch Richard R  

bioRxiv : the preprint server for biology 20241026


Understanding the origins of novel, complex phenotypes is a major goal in evolutionary biology. Poison frogs of the family Dendrobatidae have evolved the novel ability to acquire alkaloids from their diet for chemical defense at least three times. However, taxon sampling for alkaloids has been biased towards colorful species, without similar attention paid to inconspicuous ones that are often assumed to be undefended. As a result, our understanding of how chemical defense evolved in this group i  ...[more]

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