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Identification of endogenous, natural RBRP peptide encoded by lncRNA LINC00266-1 in tumor tissue

ABSTRACT: The total proteins from tumor tissues were seperated by tricine SDS-PAGE and stained with silver. The gel band with about 7kD molecular weight related to RBRP peptide was identified by LC-MS/MS.

ORGANISM(S): Homo Sapiens

SUBMITTER: Guang-Rong Yan

PROVIDER: PXD016268 | iProX | Tue Feb 25 00:00:00 GMT 2020

REPOSITORIES: iProX

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An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis.

Zhu Song S Wang Ji-Zhong JZ Chen De He Yu-Tian YT Meng Nan N Chen Min M Lu Rui-Xun RX Chen Xin-Hui XH Zhang Xiao-Lan XL Yan Guang-Rong GR

Nature communications 20200403 1

N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic RNAs. The biological importance of m6A relies on m6A readers, which control mRNA fate and function. However, it remains unexplored whether additional regulatory subunits of m6A readers are involved in the m6A recognition on RNAs. Here we discover that the long noncoding RNA (lncRNA) LINC00266-1 encodes a 71-amino acid peptide. The peptide mainly interacts wi ...[more]

PMID: 32245947

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