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Global protein data of proteomics of spleen infected by Babesia microti

ABSTRACT: Babesia is a kind of protozoa parasitic in the red blood cells of some vertebrates. Some species of Babesia can cause human and animal co-infection and do great harm. As the largest immune organ in mammals, spleen plays an important role in resisting Babesia infection. Although the spleen infected by Babesia is seriously damaged, it still initiates the immunomodulatory response actively. In order to further explore the molecular mechanism of immune regulation and self-repair of spleen in response to infection, DIA quantitative proteomics was used to analyze the changes of total protein expression and phosphorylation modification in spleen tissue of mice infected with Babesia microti, so as to explore the self-regulation mechanism of spleen in the process of injury and repair. It provides an important basis for the diagnosis and treatment of babesiosis.

ORGANISM(S): Babesia Microti

SUBMITTER: Jingze Liu

PROVIDER: PXD019236 | iProX | Sat May 16 00:00:00 BST 2020

REPOSITORIES: iProX

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Protein regulation strategies of the mouse spleen in response to Babesia microti infection.

Xue Xiaomin X Ren Shuguang S Yang Xiaohong X Masoudi Abolfazl A Hu Yuhong Y Wang Xiaoshuang X Li Hongxia H Zhang Xiaojing X Wang Minjing M Wang Hui H Liu Jingze J

Parasites & vectors 20210119 1

<h4>Background</h4>Babesia is a protozoan parasite that infects red blood cells in some vertebrates. Some species of Babesia can induce zoonoses and cause considerable harm. As the largest immune organ in mammals, the spleen plays an important role in defending against Babesia infection. When infected with Babesia, the spleen is seriously injured but still actively initiates immunomodulatory responses.<h4>Methods</h4>To explore the molecular mechanisms underlying the immune regulation and self-r ...[more]

PMID: 33468223

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