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Gut microbiota may underlie the predisposition of healthy individuals to COVID-19

ABSTRACT: The COVID-19 pandemic is spreading globally with high disparity in the susceptibility of the disease severity. Identification of the key underlying factors for this disparity is highly warranted. Here we describe constructing a proteomic risk score based on 20 blood proteomic biomarkers which predict the progression to severe COVID-19. We demonstrate that in our own cohort without infection, this proteomic risk score is positively associated with proinflammatory cytokines mainly among older, but not younger, individuals. We further discovered that a core set of gut microbiota could accurately predict the above proteomic biomarkers using a machine learning model, and that these gut microbiota features are highly correlated with proinflammatory cytokines.

ORGANISM(S): Homo Sapiens

SUBMITTER: Ju-sheng Zheng

PROVIDER: PXD019675 | iProX | Tue Jun 09 00:00:00 BST 2020

REPOSITORIES: iProX

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Circulating Proteome and Progression of Type 2 Diabetes.

Gou Wanglong W Yue Liang L Tang Xin-Yi XY Wu Yan-Yan YY Cai Xue X Shuai Menglei M Miao Zelei Z Fu Yuanqing Y Chen Hao H Jiang Zengliang Z Wang Jiali J Tian Yunyi Y Xiao Congmei C Xiang Nan N Wu Zhen Z Chen Yu-Ming YM Guo Tiannan T Zheng Ju-Sheng JS

The Journal of clinical endocrinology and metabolism 20220501 6

<h4>Context</h4>Circulating proteomes may provide intervention targets for type 2 diabetes (T2D).<h4>Objective</h4>We aimed to identify proteomic biomarkers associated with incident T2D and assess its joint effect with dietary or lifestyle factors on the T2D risk.<h4>Methods</h4>We established 2 nested case-control studies for incident T2D: discovery cohort (median 6.5 years of follow-up, 285 case-control pairs) and validation cohort (median 2.8 years of follow-up, 38 case-control pairs). We int ...[more]

PMID: 35184183

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