Impaired O-GlcNAcylation rather than N-glycosylation caused by AtAGM deficiency leads to growth variations in Arabidopsis thaliana
Ontology highlight
ABSTRACT:
ORGANISM(S): Arabidopsis Thaliana
SUBMITTER: 
Heng Yin
PROVIDER: PXD024977 | iProX | Thu Mar 25 00:00:00 GMT 2021
REPOSITORIES: iProX
Publications
Protein O-GlcNAcylation impairment caused by N-acetylglucosamine phosphate mutase deficiency leads to growth variations in Arabidopsis thaliana.
Jia Xiaochen X Zhang Hongyan H Qin Hongqiang H Li Kuikui K Liu Xiaoyan X Wang Wenxia W Ye Mingliang M Yin Heng H
The Plant journal : for cell and molecular biology 20230309 3
As an essential enzyme in the uridine diphosphate (UDP)-GlcNAc biosynthesis pathway, the significant role of N-acetylglucosamine phosphate mutase (AGM) remains unknown in plants. In the present study, a functional plant AGM (AtAGM) was identified from Arabidopsis thaliana. AtAGM catalyzes the isomerization of GlcNAc-1-P and GlcNAc-6-P, and has broad catalytic activity on different phosphohexoses. UDP-GlcNAc contents were significantly decreased in AtAGM T-DNA insertional mutants, which caused te ...[more]
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