Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: Ling Leng
PROVIDER: PXD025613 | iProX | Mon Apr 26 00:00:00 BST 2021
REPOSITORIES: iProX
Ma Jie J Li Wei W Cao Ruiyuan R Gao Dunqin D Zhang Qiyu Q Li Xiao X Li Biyou B Lv Luye L Li Mansheng M Jiang Junyi J Wang Yujie Y Li Jun J Wu Zhihong Z Zhu Yunping Y Zhong Wu W Zhang Shuyang S Leng Ling L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20220322 16
Localized scleroderma (LoS) is a rare chronic disease with extensive tissue fibrosis, inflammatory infiltration, microvascular alterations, and epidermal appendage lesions. However, a deeper understanding of the pathogenesis and treatment strategies of LoS is currently limited. In the present work, a proteome map of LoS skin is established, and the pathological features of LoS skin are characterized. Most importantly, a human-induced pluripotent stem cell-derived epithelial and mesenchymal (EM) ...[more]