Application of an iPSC-derived Organoid Model for Located Scleroderma Therapy

ABSTRACT: Scleroderma is a chronic connective tissue disease characterized by skin thickening and plaque morphea, as well as hard, shiny skin. Serious involvement is observed from the superficial dermis down to the fascia and muscle. However, this condition is difficult to treat and evaluate. In this study, induced pluripotent stem cell (iPSC)-derived 3D epithelial and mesenchymal organoids were used for localized scleroderma therapy.

ORGANISM(S): Mus Musculus

SUBMITTER: Ling Leng  

PROVIDER: PXD025613 | iProX | Mon Apr 26 00:00:00 BST 2021

REPOSITORIES: iProX