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Integration of Urine Proteomic and Metabolomic profiling Reveals Novel Insights into Neuroimmune Dysfunction in Autism Spectrum Disorder

ABSTRACT: Autism spectrum disorder (ASD) is a complex set of neurodevelopmental diseases. However, the etiology and pathogenesis of ASD is largely unknown. An integrated proteomics and metabolomics approach was performed on urine sampled from diagnosed ASD children and typical children. All urine protein samples (n= 160) were subjected to data-independent acquisition proteomic analysis and 60 urine samples underwent liquid chromatography-mass spectrometry based on metabolomic analysis. So, this study presents an overview of the molecular mechanism of ASD and offers some potential targets for further early screening.

ORGANISM(S): Homo Sapiens

SUBMITTER: Juan Wang

PROVIDER: PXD031652 | iProX | Fri Feb 11 00:00:00 GMT 2022

REPOSITORIES: iProX

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Integration of Urine Proteomic and Metabolomic Profiling Reveals Novel Insights Into Neuroinflammation in Autism Spectrum Disorder.

Liu Wenlong W Li Liming L Xia Xiaochun X Zhou Xulan X Du Yukai Y Yin Zhaoqing Z Wang Juan J

Frontiers in psychiatry 20220509

Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders whose etiology and pathogenesis are not fully understood. To gain insight into the molecular basis of ASD, we performed comparative integrated proteomic and metabolomic analyses of urine samples from children diagnosed with ASD and healthy children. All 160 samples underwent proteomics analysis and 60 were analyzed by liquid chromatography-mass spectrometry to obtain metabolite profiles. We identified 77 differentia ...[more]

PMID: 35615451

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