Dataset Information

Immune Responses to multi-frequency of 1.5GHz and 4.3GHz microwave exposure in rats

ABSTRACT: In this study, we exposed the rats to 1.5 GHz (L10), 4.3 GHz (C10) or multi-frequency (LC10) microwave at an av-erage power density of 10 mW/cm2. Both single and multi-frequency microwave induced slight pathological changes in thymus and spleen. And, the white blood cells (WBCs) and lymphocytes in peripheral blood were decreased at 6 h and 7 d after exposure, suggesting immune suppressive responses were induced. Among lymphocytes, the B lymphocytes were increased while the T lymphocytes were decreased at 7 d after exposure in C10 and LC10 groups, but not in L10 group. Moreover, multi-frequency microwave regulated the B and T lymphocytes stronger than C band microwave. The results of proteomics showed that both single and mul-ti-frequency microwave regulated numerous genes associated with immune regulation and cel-lular metabolism in peripheral blood and spleen. However, multi-frequency microwave altered the expression of much more proteins. Moreover, multi-frequency microwave down-regulated T lymphocytes development, differentiation and activation associated proteins, while up-regulated B lymphocytes activation related proteins. In conclusion, multi-frequency mi-crowave of 1.5 GHz and 4.3 GHz produced immune suppressive responses via regulating im-mune regulation and cellular metabolism associated proteins. Our findings provided meaningful information for exploring potential mechanisms underlying multi-frequency induced immune suppression.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Ruiyun Peng

PROVIDER: PXD034706 | iProX | Mon Jun 20 00:00:00 BST 2022

REPOSITORIES: iProX

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Publications

Immune Responses to Multi-Frequencies of 1.5 GHz and 4.3 GHz Microwave Exposure in Rats: Transcriptomic and Proteomic Analysis.

Zhao Li L Yao Chuanfu C Wang Hui H Dong Ji J Zhang Jing J Xu Xinping X Wang Haoyu H Yao Binwei B Ren Ke K Sun Liu L Peng Ruiyun R

International journal of molecular sciences 20220622 13

With the rapidly increasing application of microwave technologies, the anxiety and speculation about microwave induced potential health hazards has been attracting more and more attention. In our daily life, people are exposed to complex environments with multi-frequency microwaves, especially L band and C band microwaves, which are commonly used in communications. In this study, we exposed rats to 1.5 GHz (L10), 4.3 GHz (C10) or multi-frequency (LC10) microwaves at an average power density of 1 ...[more]

PMID: 35805954

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Dataset Information

Immune Responses to multi-frequency of 1.5GHz and 4.3GHz microwave exposure in rats

Publications

Immune Responses to Multi-Frequencies of 1.5 GHz and 4.3 GHz Microwave Exposure in Rats: Transcriptomic and Proteomic Analysis.

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