Mass spectrometry analysis of in vitro kinase assay for DNA-PKcs and TAF7
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Zhanjun Jia
PROVIDER: PXD036930 | iProX | Thu Sep 22 00:00:00 BST 2022
REPOSITORIES: iProX
Publications
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) drives chronic kidney disease progression in male mice.
Yang Yunwen Y Liu Suwen S Wang Peipei P Ouyang Jing J Zhou Ning N Zhang Yue Y Huang Songming S Jia Zhanjun Z Zhang Aihua A
Nature communications 20230311 1
Kidney injury initiates epithelial dedifferentiation and myofibroblast activation during the progression of chronic kidney disease. Herein, we find that the expression of DNA-PKcs is significantly increased in the kidney tissues of both chronic kidney disease patients and male mice induced by unilateral ureteral obstruction and unilateral ischemia-reperfusion injury. In vivo, knockout of DNA-PKcs or treatment with its specific inhibitor NU7441 hampers the development of chronic kidney disease in ...[more]
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