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Discovery of plasma biomarkers for venous thromboembolism in non-small cell lung cancer through data-independent acquisition mass spectrometry

ABSTRACT: Proteomics is a science that studies the composition of proteins in cells, tissues or organisms and their changing laws, taking the proteome as the research object. Proteomics essentially refers to the study of protein characteristics at a large-scale level, including protein expression levels, post-translational modifications, protein-protein interactions, etc., thereby obtaining information on disease occurrence, cell metabolism, etc. at the protein level. A holistic and comprehensive understanding of the process.

ORGANISM(S): Human Blood Metagenome

SUBMITTER: Lan Gao

PROVIDER: PXD037222 | iProX | Sun Oct 09 00:00:00 BST 2022

REPOSITORIES: iProX

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Discovery of protein biomarkers for venous thromboembolism in non-small cell lung cancer patients through data-independent acquisition mass spectrometry.

Liu Yanhong Y Gao Lan L Fan Yanru Y Ma Rufei R An Yunxia Y Chen Guanghui G Xie Yan Y

Frontiers in oncology 20230209

<h4>Objective</h4>Non-small cell lung cancer (NSCLC) patients present a high incidence of venous thromboembolism (VTE) with poor prognosis. It is crucial to identify and diagnose VTE early. The study aimed to identify potential protein biomarkers and mechanism of VTE in NSCLC patients <i>via</i> proteomics research.<h4>Methods</h4>Proteomic analysis of the human plasma was performed through data-independent acquisition mass spectrometry for 20 NSCLC patients with VTE, and 15 NSCLC patients witho ...[more]

PMID: 36874092

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