Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A new long-acting tissue kallikrein ameliorates ischemic stroke injury by inhibiting HMGB1-related neuroinflammation and apoptosis

ABSTRACT: The proteomics analysis of total proteins extracted from the cerebral ischemic penumbra tissues of different groups three days after MCAO

ORGANISM(S): Mus Musculus

SUBMITTER: Xiang Cao

PROVIDER: PXD042777 | iProX | Wed Jun 07 00:00:00 BST 2023

REPOSITORIES: iProX

ACCESS DATA

Json Xml

Publications

QHRD106 ameliorates ischemic stroke injury as a long-acting tissue kallikrein preparation.

Xu Si-Yi SY Jia Jun-Qiu JQ Sun Min M Bao Xin-Yu XY Xia Sheng-Nan SN Shu Shu S Liu Pin-Yi PY Ji Sen-Lin SL Ye Lei L Cao Xiang X Xu Yun Y

iScience 20230703 7

Ischemic stroke is the second leading cause of death worldwide, and there are limited effective treatment strategies. QHRD106, a polyethyleneglycol (PEG)-modified long-acting tissue kallikrein preparation, has not been reported previously. In this study, we aimed to investigate the therapeutic effect of QHRD106 in ischemic stroke and its possible mechanism. We found that QHRD106 treatment alleviated brain injury after stroke via bradykinin (BK) receptor B2 (B2R) instead of BK receptor B1 (B1R). ...[more]

PMID: 37496671

Similar Datasets

A new long-acting tissue kallikrein ameliorates ischemic stroke injury by inhibiting HMGB1-related neuroinflammation and apoptosis-ip

Project description:Coimmunoprecipitation, detect binding protein of HMGB1 in primary microglials in control and LPS group

2023-06-07 | PXD042778 |

Ischemic stroke mice brain LC-MSMS

Project description:This study determined the influence of myeloid cell Trim59 deficiency on experimental stroke outcomes and the cerebral proteomic profile using myeloid cell Trim59 conditional knockout (Trim59-cKO) mice, the middle cerebral artery occlusion/reperfusion ischemic model, and a label-free quantitative proteomic profiling technique.

2024-08-02 | PXD049258 | Pride

Microglial IL-1RA ameliorates brain injury after ischemic stroke by inhibiting astrocytic CXCL1-mediated neutrophil recruitment and microvessel occlusion

Project description:To invesitgate effect of microglial depletion on acute ischemic stroke

2023-03-29 | GSE227186 | GEO

CircRNA as Predictive Biomarker of Penumbra in Acute Ischemic Stroke

Project description:Acute ischemic stroke (AIS) is a leading cause of disability and mortality worldwide. By high-throughput sequencing of infarct and ischemic penumbra tissue from middle cerebral artery embolization (MCAO) mice, we identified the CircRNA expression was dramatically and selectively regulated in the penumbra tissues.

2022-11-01 | GSE186103 | GEO

LFQ of mouse brain in ischemic stroke

Project description:Ischemic disorders are the leading cause of death worldwide. The extracellular signal-regulated kinases 1 and 2 (ERK1/2) are part of the Raf/MEK/ERK1/2 cascade and are thought to affect the outcome of ischemic stroke. However, it is under debate whether activation or inhibition of ERK1/2 is beneficial. Therefore, this study aimed to investigate the impact of ERK1/2 after cerebral ischemia using transgenic mice with ubiquitous overexpression of ERK2 or of the Raf kinase inhibitor protein (RKIP), an inhibitor of the ERK1/2 signaling cascade.

2022-02-17 | PXD030067 | Pride

QHRD106 ameliorates ischemic stroke injury as a long-acting tissue kallikrein preparation.

Project description:Ischemic stroke is the second leading cause of death worldwide, and there are limited effective treatment strategies. QHRD106, a polyethyleneglycol (PEG)-modified long-acting tissue kallikrein preparation, has not been reported previously. In this study, we aimed to investigate the therapeutic effect of QHRD106 in ischemic stroke and its possible mechanism. We found that QHRD106 treatment alleviated brain injury after stroke via bradykinin (BK) receptor B2 (B2R) instead of BK receptor B1 (B1R). Mechanistically, QHRD106 reduced high-mobility group box 1 (HMGB1)-induced apoptosis and inflammation after ischemic stroke in vivo and in vitro. Moreover, we confirmed that QHRD106 reduced the level of acetylated HMGB1 and reduced the binding between heat shock protein 90 alpha family class A member 1 (HSP90AA1) and HMGB1, thus inhibiting the translocation and release of HMGB1. In summary, these findings indicate that QHRD106 treatment has therapeutic potential for cerebral ischemic stroke.

| S-EPMC10366503 | biostudies-literature

The role of a mammalian network in regulating ischemic stroke outcome II

Project description:To detect mRNAs in ischemic stroke animals we dissected contralateral (CL) and peri-ischemic (PI) cortex of transient middle cerebral artery occlusion (tMCAo) mice wild-type and ciRS-7 KO We performed differentially expression analysis of RNA-seq of wild-type and ciRS-7 KO tMCAo ischemic mice

2023-01-31 | GSE213177 | GEO

RNA Sequencing Analysis of Brain Transcriptomes of Ischemic Stroke Treated With or Without Lactate

Project description:We report the application of RNA sequencing technology for high-throughput profiling of brain transcriptomes in ischemic stroke mice. We find that changes in gene expression were detected in vehicle-treated ischemic brains when compared with the sham groups, with 1159 upregulated genes and 529 downregulated genes. While, the lactate preconditioning further enlarged the changes in gene expression of ischemic brains, with 2071 upregulated genes and 1003 downregulated genes. Finally, we show that the ischemic brains are much more immunologically activated by the lactate treatment. This study shows that the contributing roles of lactate in the brain injury after cerebral ischemia are complex and immunological mechanisms may be the major effects that exacerbate the brain injury of mice with cerebral ischemia.

2024-08-14 | GSE183439 | GEO

Transcription profiling of human MCA leading to the ischemic area from patients died due to ischemic stroke vs. expression in equivalent MCA in control subjects deceased due to extra cerebral causes

Project description:Comparison of the gene expression in human MCA leading to the ischemic area from patients died due to ischemic stroke in comparison the the expression in the equivalent MCA in control subjects deceased due to extra cerebral causes.

2005-06-15 | E-MEXP-249 | biostudies-arrayexpress

Single nucleus transcriptome of the brains response to ischemic stroke

Project description:The mammalian brain consists of heterogeneous cell populations with distinct responses to injury. Here we used single nucleus RNA sequencing (snRNAseq) to analyze cell type specific transcriptional responses of the rodent brain to ischemic stroke, 48h after the induction of middle cerebral artery occlusion.

2024-06-29 | GSE250245 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data