Different expressed proteins of HIV-infected long-term non-progressors (LTNPs) and regular progressors (RPs)
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Wenyan Zhang
PROVIDER: PXD046078 | iProX | Thu Oct 12 00:00:00 BST 2023
REPOSITORIES: iProX
Publications
RPLP1 restricts HIV-1 transcription by disrupting C/EBPβ binding to the LTR.
Yang Weijing W Wang Hong H Li Zhaolong Z Zhang Lihua L Liu Jianhui J Kirchhoff Frank F Huan Chen C Zhang Wenyan W
Nature communications 20240621 1
Long-term non-progressors (LTNPs) of HIV-1 infection may provide important insights into mechanisms involved in viral control and pathogenesis. Here, our results suggest that the ribosomal protein lateral stalk subunit P1 (RPLP1) is expressed at higher levels in LTNPs compared to regular progressors (RPs). Functionally, RPLP1 inhibits transcription of clade B HIV-1 strains by occupying the C/EBPβ binding sites in the viral long terminal repeat (LTR). This interaction requires the α-helixes 2 and ...[more]
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