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Extracellular vesicles from Methicillin-resistant Staphylococcus aureus-infected alveolar macrophages induce necroptosis

ABSTRACT: Staphylococcus aureus (S. aureus), a major cause of hospital and community-acquired pneumonia, still has a high mortality rate. Extracellular vesicles (EVs), as crucial mediators of intercellular communication, have a significant impact on infectious diseases. However, the role of EVs from alveolar macrophages (AMs) in S. aureus pneumonia remains unclear.

ORGANISM(S): Mus Musculus

SUBMITTER: Gensheng Zhang

PROVIDER: PXD052452 | iProX | Tue May 21 00:00:00 BST 2024

REPOSITORIES: iProX

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Extracellular vesicles from alveolar macrophages harboring phagocytosed methicillin-resistant Staphylococcus aureus induce necroptosis.

Bai Songjie S Wen Xuehuan X Li Bingyu B Hu Ruomeng R Yang Jie J Yu Qing Q Zeng Xianchang X Feng Huajun H Zhu Feng F Cai Zhijian Z Zhang Gensheng G

Cell reports 20240709 7

Methicillin-resistant Staphylococcus aureus (MRSA) infection, a major cause of hospital- and community-acquired pneumonia, still has a high mortality rate. Extracellular vesicles (EVs), as crucial mediators of intercellular communication, have a significant impact on infectious diseases. However, the role of EVs from alveolar macrophages (AMs) in MRSA pneumonia remains unclear. We report that AMs phagocytose MRSA and release more EVs in mice with MRSA pneumonia. EVs from AMs harboring phagocytos ...[more]

PMID: 38985677

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