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Fusing Engineered Bacterial Strains with NIR-II AIEgen for Multimodal Image-guided Phototherapy and Immunotherapy

ABSTRACT: we present an aggregation-induced emission (AIE) - bacteria hybrid bionic robot to address the above issues. This bionic robot is composed of a multifunctional AIE molecule, INX-2 and Escherichia coli Nissle 1917 (EcN), i.e. EcN@INX-2. The robot is characterized by NIR-II fluorescence emission with efficient photodynamic and photothermal effects and tumor targeting, which was realized by INX-2 and EcN respectively, EcN@INX-2 achieved in vivo multimodal imaging and therapy of the tumors through multiple mechanisms including the activation of anti-tumor immunity, photodynamic and photothermal therapy in CT26 tumor-bearing female mice.

ORGANISM(S): Mus Musculus

SUBMITTER: Ying Li

PROVIDER: PXD056926 | iProX | Fri Oct 18 00:00:00 BST 2024

REPOSITORIES: iProX

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Aggregation induced emission luminogen bacteria hybrid bionic robot for multimodal phototheranostics and immunotherapy.

Zhu Liwei L Song Guangjie G Zhang Wentian W Wu Yifan Y Chen Yuling Y Song Jiayi J Wang Deliang D Li Guoxin G Tang Ben Zhong BZ Li Ying Y

Nature communications 20250316 1

Multimodal phototheranostics utilizing single molecules offer a "one-and-done" approach, presenting a convenient and effective strategy for cancer therapy. However, therapies based on conventional photosensitizers often suffer from limitations such as a single photosensitizing mechanism, restricted tumor penetration and retention, and the requirement for multiple irradiations, which significantly constrain their application. In this report, we present an aggregation-induced emission luminogen (A ...[more]

PMID: 40089477

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