Dataset Information

Pan-Cancer Proteogenomic Characterization of Metastatic Brain Tumors

ABSTRACT: 4D-DIA data Derived from Paired Primary Tumors, Brain Metastasis and Giloblastoma

ORGANISM(S): Homo Sapiens

SUBMITTER: Gao Zhang

PROVIDER: PXD059751 | iProX | Mon Jan 20 00:00:00 GMT 2025

REPOSITORIES: iProX

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Publications

A proteogenomic atlas of 1032 brain metastases identifies molecular subtypes, immune landscapes, and therapeutic vulnerabilities.

Yang Zhenyu Z Wei Shiyou S Duan Hao H Wang Xiuqi X Zhang Dainan D Kiang Karrie Mei-Yee KM Deng Yulan Y Yang Yuanzhong Y Ku Yin Y Hu Wanming W Zou Chaowei C Tang Meiqin M Jiang Yu Y Liu Yu Y Lan Hongbin H Chen Zexin Z Leung Gilberto Ka-Kit GK Jia Wang W Mou Yonggao Y Liu Lunxu L Zhang Gao G

Nature communications 20260126 1

The molecular heterogeneity of brain metastases hampers therapeutic development for cures. To address this unmet and urgent need, we construct a comprehensive multi-omic, single cell, and spatially resolved atlas of 1,032 pan-cancer brain metastases, identifying four robust molecular subtypes with distinct biological programs and clinical associations. These brain metastases subtypes (BrMS) are defined by unique biological states: neural-like (BrMS1), metabolic (BrMS3), highly proliferative/immu ...[more]

PMID: 41587979

Dataset Information

Pan-Cancer Proteogenomic Characterization of Metastatic Brain Tumors

Publications

A proteogenomic atlas of 1032 brain metastases identifies molecular subtypes, immune landscapes, and therapeutic vulnerabilities.

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