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4D label-free quantitative lactylproteomics analysis of breast cancer cells

ABSTRACT: 4D label-free quantitative lactylproteomics analysis was performed to identify the differentially lactylated proteins between human normal mammary epithelial cell line (MCF 10A) and BC cells (MCF7, T-47D, and MDA-MB-468)

ORGANISM(S): Homo Sapiens

SUBMITTER: Hao Wu

PROVIDER: PXD060185 | iProX | Fri Jan 24 00:00:00 GMT 2025

REPOSITORIES: iProX

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H4K79 and H4K91 histone lactylation, newly identified lactylation sites enriched in breast cancer.

Liu Jiena J Zhao Liuying L Yan Meisi M Jin Shengye S Shang Lingmin L Wang Jianyu J Wang Qin Q Zhao Shilu S Shen Zibo Z Liu Tong T Wu Hao H Pang Da D

Journal of experimental & clinical cancer research : CR 20250823 1

Metabolic reprogramming and epigenetic modification are two hallmarks of cancer. Protein lysine lactylation (Kla) is a novel type of glycolysis lactate-triggered posttranslational modification. However, the role of Kla in breast cancer (BC) remains largely unknown. Here, western blot, and immunohistochemical (IHC) staining of BC tissues revealed that global Kla levels were upregulated in BC tissues, and high levels of Kla were correlated with poor prognosis of patients with BC. A series of in vi ...[more]

PMID: 40849487

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