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Proteomic changes of tumor drug-resistant cells after drug treatment

ABSTRACT: Whole proteome and ribosome-nascent-chain complex (RNC) changes of A549 cisplatin-resistant cells after treated with aurintricarboxylic acid

ORGANISM(S): Homo Sapiens

SUBMITTER: Gong Zhang

PROVIDER: PXD061028 | iProX | Thu Feb 20 00:00:00 GMT 2025

REPOSITORIES: iProX

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Aurintricarboxylic acid inhibits the malignant phenotypes of drug-resistant cells via translation regulation.

Shang Keke K Chen Yang Y Jin Jingjie J Wang Tong T Zhang Gong G

Frontiers in oncology 20250514

Genome instability, a hallmark of cancer, leads to endless mutations that eventually cause drug resistance against almost all chemotherapy drugs. This poses a significant obstacle to the success of cancer treatments. Here, we report that aurintricarboxylic acid (ATCA) effectively suppresses the malignant phenotypes, including proliferation, migration, invasion, and clone formation, of cancer cells of multiple cancers, including cisplatin-resistant lung cancer cells, paclitaxel-resistant lung can ...[more]

PMID: 40438682

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