Dataset Information
Bifidobacterium bifidum-derived nanoparticles
Ontology highlight
ABSTRACT:
ORGANISM(S): Bifidobacterium Bifidum
SUBMITTER: 
Pinglan Li
PROVIDER: PXD061375 | iProX | Sat Mar 01 00:00:00 GMT 2025
REPOSITORIES: iProX
Publications
Bifidobacterium bifidum-derived nanoparticles attenuate alcoholic liver disease via enhanced hepatic phagocytosis and gastrointestinal homeostasis.
Nature communications 20260430
Alcohol-associated liver disease (ALD) has limited therapeutic options due to its complex pathogenesis. This study demonstrates the ALD-protective effects of extracellular nanoparticles derived from Bifidobacterium bifidum (BNPs), focusing on the concept of gut microbiota-derived nanoparticles (GNPs) in disease pathogenesis. When isolated BNPs were administered in an ALD mouse model, they upregulated Vsig4 receptor expression in liver macrophages, improving phagocytic clearance of harmful GNPs t ...[more]
