Structural-guided identification of two novel modulators of β-1,3-glucan synthase FKS1
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ABSTRACT: FKS1 is a β-1,3-glucan synthase that plays a critical role in fungal cell wall formation and serves as a key target for antifungal drugs such as echinocandin and ibrexafungerp. However, the molecular mechanisms regulating FKS1 activity remain largely unknown. This study identifies its endogenous inhibitor and stabilizing factor
ORGANISM(S): Saccharomyces Cerevisiae
SUBMITTER:
Xiang Wang
PROVIDER: PXD062062 | iProX | Thu Mar 20 00:00:00 GMT 2025
REPOSITORIES: iProX
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