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DIA proteomics of virgin female Schistosoma mansoni after BATT induction

ABSTRACT: Schistosomiasis, a zoonotic parasitic disease caused by trematodes of the genus Schistosoma, represents a significant zoonotic parasitic disease that affects over 200 million people across 78 countries, with a substantial burden on public health systems globally. The phenomenon of male-induced sexual maturation in female schistosomes was first documented as early as 1928. However, the molecular mechanisms underlying this interaction remain poorly understood and have yet to be fully elucidated. In a significant advancement, a recent study identified a novel mechanism through which the male schistosome synthesizes a dipeptide pheromone, beta-alanyl-tryptamine (BATT), which acts as a key inducer of female reproductive development.This study aimed to answer how female schistosome initiate the sexual maturation process upon receiving BATT signals.

ORGANISM(S): Schistosoma Mansoni

SUBMITTER: Jipeng Wang

PROVIDER: PXD067676 | iProX | Mon Aug 25 00:00:00 BST 2025

REPOSITORIES: iProX

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A male-pheromone-elevated transcription factor ZNF362.1 in female schistosomes determines sexual maturation.

Gu Mengjie M Cheng Wenjun W Li Shan S Chen Gongwen G Chen Xu X Jiang Ruiqi R Yuan Minwei M Wang Jing J Zhang Wei W Yi Cun C Xie Yuxiang Y Wang Xiaoling X Hu Wei W Wang Jipeng J

Science advances 20260306 10

Egg production by female schistosomes drives both transmission and pathology of schistosomiasis, affecting over 200 million people. Female maturation relies on the male-derived pheromone β-alanyl-tryptamine (BATT), but underlying molecular mechanisms are unclear. We identified the BATT-responsive transcription factor gene znf362 as a key regulator of female reproductive development. Functional studies showed that znf362.1, but not znf362.2, is essential for BATT-induced ovar ...[more]

PMID: 41790879

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