Stable Coordination Unlocks Ligand-accelerated Transition Metal Catalysis on Proteins

ABSTRACT: This project investigates in situ deprotection reactions catalyzed by the Ni–BCS system in MC38 cells and the subsequent impact on the immunopeptidome. Two independent MC38 cell preparations (2 × 10⁷ cells each) were pulsed with either the P2 peptide or P2 peptide followed by Ni–BCS catalyzed in situ deprotection (P2+Ni). MHC-associated peptides were analysed by Immunoprecipitation-Mass Spectrometry.

ORGANISM(S): Mus Musculus

SUBMITTER: Jie Li  

PROVIDER: PXD067964 | iProX | Tue Sep 02 00:00:00 BST 2025

REPOSITORIES: iProX