Proteomics

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Thymol and carvacrol alleviate intestinal inflammation in lambs via the Romboutsia maritimum-benzyl cinnamate-GALNT7/MUC2 axis


ABSTRACT: Dietary supplementation with thymol and carvacrol (CAT) effectively mitigated intestinal inflammation in diarrheic lambs. Multi-omics integrative analyses demonstrated that CAT selectively enriched Romboutsia maritimum, whose metabolic activity led to the production of benzyl cinnamate—a microbial metabolite with potent anti-inflammatory properties. Mechanistically, benzyl cinnamate activated the host glycosyltransferase GALNT7 to upregulate MUC2 expression, thereby promoting mucosal barrier restoration and counteracting E. coli (O157:H7)–induced intestinal injury.

ORGANISM(S): Capra Hircus

SUBMITTER: Yuxin Yang  

PROVIDER: PXD070212 | iProX | Mon Nov 03 00:00:00 GMT 2025

REPOSITORIES: iProX

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