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Proteomic profiling of in vitro differentiated WT and eIF4G2 knockout B cells

ABSTRACT: eIF4G2 (also known as DAP5 or NAT1) is a translation initiation factor. By generating Eif4g2fl/fl;Cγ1-Cre mice, in which the expression of Cre recombinase is induced by transcription of the Ig gamma1 constant region gene segment and deletes Eif4g2 in activated B cells, we found eIF4G2 is essential for plasma cell differentiation. The experiment aimed to identify changes in the global proteome resulting from the deletion of eIF4G2.

ORGANISM(S): Mus Musculus

SUBMITTER: Changchun Xiao

PROVIDER: PXD071241 | iProX | Wed Nov 26 00:00:00 GMT 2025

REPOSITORIES: iProX

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