Based on multi-omics, revealing the key role of MOESIN lactic acidification-driven TGF-β signaling axis in improving diabetic osteoporosis through gut microbiota

ABSTRACT: Diabetic osteoporosis (DOP), as a typical representative of metabolic-immune cross-talk imbalance, has an unclear pathogenesis and lacks effective targeted intervention methods. This study aims to systematically analyze the molecular mechanism by which fecal microbiota transplantation (FMT) activates the TGF-β signaling axis through MOESIN lactic acid modification, reshapes the Treg/Th17 immune balance, and improves the pathological process of DOP based on multi-omics integrated analysis

ORGANISM(S): Mus Musculus

SUBMITTER: Jiajia Lu  

PROVIDER: PXD076650 | iProX | Fri Apr 03 00:00:00 BST 2026

REPOSITORIES: iProX