Proteomics

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Development of Dual-Mechanism Small-Molecule Degraders for Treatment of Advanced Prostate Cancer


ABSTRACT: In this study, we present the discovery, mechanistic insights, and preclinical validation of a potent, selective small-molecule drug candidate with dual PROTAC and molecular glue mechanisms that target human androgen receptors. This drug lead shows remarkable therapeutic potential on various drug-resistant prostate cancers.

ORGANISM(S): Homo Sapiens

SUBMITTER: Xiaoguang Lei  

PROVIDER: PXD078789 | iProX | Sat May 23 00:00:00 BST 2026

REPOSITORIES: iProX

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