Development of Dual-Mechanism Small-Molecule Degraders for Treatment of Advanced Prostate Cancer
Ontology highlight
ABSTRACT: In this study, we present the discovery, mechanistic insights, and preclinical validation of a potent, selective small-molecule drug candidate with dual PROTAC and molecular glue mechanisms that target human androgen receptors. This drug lead shows remarkable therapeutic potential on various drug-resistant prostate cancers.
ORGANISM(S): Homo Sapiens
SUBMITTER:
Xiaoguang Lei
PROVIDER: PXD078789 | iProX | Sat May 23 00:00:00 BST 2026
REPOSITORIES: iProX
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